Vikram starts from where Lokesh's Kaithi left off. Months after Tamil Nadu police's biggest drug bust ever, two containers full of drugs went missing in Chennai, and local gangs must retrieve them at any cost in front of the crime lord and leader of the drug mafia Rolex – by The role played by Surya – pays everyone. Meanwhile, a group of masked men are on a killing spree, taking the lives of some high-ranking officers, including a young officer in the Narcotics Control Bureau, played by Kalidas.